The Barber Lab aims to understand how chemical and mechanical cues such as growth factors, wounding or tensional forces regulate cell migration, actin cytoskeleton remodeling, and proliferation. We also study the role of these processes in cancer progression and metastasis. Our focus is determining how intracellular pH dynamics induced by extracellular cues control cell migration and proliferation, with recent projects including metabolic adaptation. Our studies from molecules to cells address questions on how changes in pH regulate protein conformations to determine activities, ligand-binding affinities, and stability, modulate signaling networks, and control normal and disease cell processes.