Fred Chang, PhD, MD

Professor
Cell and Tissue Biology
[email protected]
+1 415 476-8922
The Chang Lab studies cell morphogenesis and cell division. We are interested in fundamental questions concerning spatial organization within a single cell: How do cellular components organize to form cells of a specific size and shape? How might cells sense their own shape and size? Topics include: cytokinesis, placement of the cell division plane, cell polarity, dynamics of microtubules and actin, biomechanics of cell morphogenesis, and sensing of cell shape and size. Many of our studies are on the simple rod-shaped fission yeast Schizosaccharomyces pombe.
Publications: 

Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization.

Developmental cell

Molines AT, Lemière J, Gazzola M, Steinmark IE, Edrington CH, Hsu CT, Real-Calderon P, Suhling K, Goshima G, Holt LJ, Thery M, Brouhard GJ, Chang F

Starvation induces shrinkage of the bacterial cytoplasm.

Proceedings of the National Academy of Sciences of the United States of America

Shi H, Westfall CS, Kao J, Odermatt PD, Anderson SE, Cesar S, Sievert M, Moore J, Gonzalez CG, Zhang L, Elias JE, Chang F, Huang KC, Levin PA

Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast.

eLife

Odermatt PD, Miettinen TP, Lemiere J, Kang JH, Bostan E, Manalis SR, Huang KC, Chang F

Precise regulation of the relative rates of surface area and volume synthesis in bacterial cells growing in dynamic environments.

Nature communications

Shi H, Hu Y, Odermatt PD, Gonzalez CG, Zhang L, Elias JE, Chang F, Huang KC

Decoupling of Rates of Protein Synthesis from Cell Expansion Leads to Supergrowth.

Cell systems

Knapp BD, Odermatt P, Rojas ER, Cheng W, He X, Huang KC, Chang F

Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.

Molecular biology of the cell

Zhurinsky J, Salas-Pino S, Iglesias-Romero AB, Torres-Mendez A, Knapp B, Flor-Parra I, Wang J, Bao K, Jia S, Chang F, Daga RR

Reprogramming Cdr2-Dependent Geometry-Based Cell Size Control in Fission Yeast.

Current biology : CB

Facchetti G, Knapp B, Flor-Parra I, Chang F, Howard M

Who's Your DadA? d-Alanine Levels Regulate Bacterial Stiffness.

mBio

Odermatt PD, Arjes HA, Chang F, Huang KC

The outer membrane is an essential load-bearing element in Gram-negative bacteria.

Nature

Rojas ER, Billings G, Odermatt PD, Auer GK, Zhu L, Miguel A, Chang F, Weibel DB, Theriot JA, Huang KC

The XMAP215 Ortholog Alp14 Promotes Microtubule Nucleation in Fission Yeast.

Current biology : CB

Flor-Parra I, Iglesias-Romero AB, Chang F

Forces that shape fission yeast cells.

Molecular biology of the cell

Chang F

Morphogenesis of the Fission Yeast Cell through Cell Wall Expansion.

Current biology : CB

Atilgan E, Magidson V, Khodjakov A, Chang F

Electrochemical regulation of budding yeast polarity.

PLoS biology

Haupt A, Campetelli A, Bonazzi D, Piel M, Chang F, Minc N

The contractile ring coordinates curvature-dependent septum assembly during fission yeast cytokinesis.

Molecular biology of the cell

Zhou Z, Munteanu EL, He J, Ursell T, Bathe M, Huang KC, Chang F

How and why cells grow as rods.

BMC biology

Chang F, Huang KC

Electrochemical control of cell and tissue polarity.

Annual review of cell and developmental biology

Chang F, Minc N

Cortical regulation of cell size by a sizer cdr2p.

eLife

Pan KZ, Saunders TE, Flor-Parra I, Howard M, Chang F

Role of turgor pressure in endocytosis in fission yeast.

Molecular biology of the cell

Basu R, Munteanu EL, Chang F

Manipulating cell shape by placing cells into micro-fabricated chambers.

Methods in molecular biology (Clifton, N.J.)

Chang F, Atilgan E, Burgess D, Minc N

Csi1 links centromeres to the nuclear envelope for centromere clustering.

The Journal of cell biology

Hou H, Zhou Z, Wang Y, Wang J, Kallgren SP, Kurchuk T, Miller EA, Chang F, Jia S

Myosin Vs organize actin cables in fission yeast.

Molecular biology of the cell

Lo Presti L, Chang F, Martin SG

Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.

Molecular biology of the cell

Al-Bassam J, Kim H, Flor-Parra I, Lal N, Velji H, Chang F

Noise reduction in the intracellular pom1p gradient by a dynamic clustering mechanism.

Developmental cell

Saunders TE, Pan KZ, Angel A, Guan Y, Shah JV, Howard M, Chang F

CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.

Developmental cell

Al-Bassam J, Kim H, Brouhard G, van Oijen A, Harrison SC, Chang F

Regulation of cytokinesis by the formin cdc12p.

Current biology : CB

Yonetani A, Chang F

Cell-cycle control: don't supersize me.

Current biology : CB

Pan KZ, Chang F

Shaping fission yeast with microtubules.

Cold Spring Harbor perspectives in biology

Chang F, Martin SG

Mechanical forces of fission yeast growth.

Current biology : CB

Minc N, Boudaoud A, Chang F

Establishing new sites of polarization by microtubules.

Current biology : CB

Minc N, Bratman SV, Basu R, Chang F

Mechanisms for maintaining microtubule bundles.

Trends in cell biology

Bratman SV, Chang F

Regulation and targeting of the fission yeast formin cdc12p in cytokinesis.

Molecular biology of the cell

Yonetani A, Lustig RJ, Moseley JB, Takeda T, Goode BL, Chang F

Regulation of the formin for3p by cdc42p and bud6p.

Molecular biology of the cell

Martin SG, Rincón SA, Basu R, Pérez P, Chang F

Shaping the actin cytoskeleton using microtubule tips.

Current opinion in cell biology

Basu R, Chang F

Self-organization of microtubule bundles in anucleate fission yeast cells.

Nature cell biology

Daga RR, Lee KG, Bratman S, Salas-Pino S, Chang F

Asymmetric microtubule pushing forces in nuclear centering.

Current biology : CB

Daga RR, Yonetani A, Chang F

Regulation of cytokinesis by spindle-pole bodies.

Nature cell biology

Magidson V, Chang F, Khodjakov A

Dynamics of the formin for3p in actin cable assembly.

Current biology : CB

Martin SG, Chang F

Dynamic positioning of the fission yeast cell division plane.

Proceedings of the National Academy of Sciences of the United States of America

Daga RR, Chang F

Regulation of actin assembly by microtubules in fission yeast cell polarity.

Novartis Foundation symposium

Chang F, Feierbach B, Martin S

Intra-nuclear microtubules and a mitotic spindle orientation checkpoint.

Nature cell biology

Zimmerman S, Daga RR, Chang F

Imaging green fluorescent protein fusions in living fission yeast cells.

Methods (San Diego, Calif.)

Tran PT, Paoletti A, Chang F

Regulation of a formin complex by the microtubule plus end protein tea1p.

The Journal of cell biology

Feierbach B, Verde F, Chang F

HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.

Molecular biology of the cell

Chang F, Re F, Sebastian S, Sazer S, Luban J

Cell polarity: a new mod(e) of anchoring.

Current biology : CB

Martin SG, Chang F

The contractile ring.

Current biology : CB

Chang F, Burgess D

Yeasts make their mark.

Nature cell biology

Chang F, Peter M

Mid2p stabilizes septin rings during cytokinesis in fission yeast.

The Journal of cell biology

Berlin A, Paoletti A, Chang F

Cell biology. Formins set the record straight.

Science (New York, N.Y.)

Chang F, Peter M

Regulators of synthesis and activity of the G1 cyclins of budding yeast.

Cold Spring Harbor symposia on quantitative biology

Herskowitz I, Ogas J, Andrews BJ, Chang F

CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast.

Cell regulation

Neiman AM, Chang F, Komachi K, Herskowitz I