Jeffrey Bush, PhD

Professor and Chair
Cell and Tissue Biology
[email protected]
+1 415 476-9459
The Bush lab studies basic mechanisms by which signaling between cells coordinates mammalian morphogenesis. Understanding this control has significance beyond its fundamental importance in development since birth defects are the leading cause of death for infants during the first year of life. We utilize multiple approaches based in mouse genetics to understand fundamental signaling processes as they relate to development and disease with particular foci in the craniofacial and respiratory systems. In addition to mouse genetics approaches, we utilize human ESCs/iPSCs, biophysical approaches, genomics, and live imaging to understand the cellular and molecular control of morphogenesis.
Publications: 

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.

bioRxiv : the preprint server for biology

Casey-Clyde T, Liu SJ, Serrano JAC, Teng C, Jang YG, Vasudevan HN, Bush JO, Raleigh DR

A Suite of Mouse Reagents for Studying Amelogenesis.

bioRxiv : the preprint server for biology

Wald T, Verma A, Cooley V, Marangoni P, Cazares O, Sharir A, Sandoval EJ, Sung D, Najibi H, Drennon TY, Bush JO, Joester D, Klein OD

Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus.

American journal of medical genetics. Part A

Sy MR, Chauhan J, Prescott K, Imam A, Kraus A, Beleza A, Salkeld L, Hosdurga S, Parker M, Vasudevan P, Islam L, Goel H, Bain N, Park SM, Mohammed S, Dieterich K, Coutton C, Satre V, Vieville G, Donaldson A, Beneteau C, Ghoumid J, Van Den Bogaert K, Boogaerts A, Boudry E, Vanlerberghe C, Petit F, Bernardini L, Torres B, Mattina T, Carli D, Mandrile G, Pinelli M, Brunetti-Pierri N, Neas K, Beddow R, Tørring PM, Faletra F, Spedicati B, Gasparini P, Mussa A, Ferrero GB, Lampe A, Lam W, Bi W, Bacino CA, Kuwahara A, Bush JO, Zhao X, Luna PN, Shaw CA, Rosenfeld JA, Scott DA

Investigating Cell Fate Specification upon Nkx2-1Loss.

The FASEB Journal

Marisol A. O'Neill, Jeffrey O. Bush

Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.

Developmental dynamics : an official publication of the American Association of Anatomists

Mincer ST, Niethamer TK, Teng T, Bush JO, Percival CJ

Cellular and Molecular Regulation of Upper Lip Fusion.

The FASEB Journal

Camilla Teng, Teng Teng, Jeffrey Bush

Effects of EPHB receptors on facial morphology: non-additive interactions during mouse facial development.

The FASEB Journal

Sarah Mincer, Terren Niethamer, Teng Teng, Jeffrey Bush, Christopher Percival

NMDA receptors control development of somatosensory callosal axonal projections.

eLife

Zhou J, Lin Y, Huynh T, Noguchi H, Bush JO, Pleasure S

YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate.

Journal of dental research

Goodwin AF, Chen CP, Vo NT, Bush JO, Klein OD

Delineating the early transcriptional specification of the mammalian trachea and esophagus.

eLife

Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO

The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice within a Research Community.

G3 (Bethesda, Md.)

Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ

Morphometric Analysis of Efnb1 Dependent Palate Growth.

The FASEB Journal

Marisol Ann O'Neill, Christopher J. Percival, Jeffrey O. Bush

Hypertelorism of Efnb1 Null Mice Occurs Independently of Changes to Underlying Brain Shape.

The FASEB Journal

Christopher J Percival, Jay Devine, Terren Niethamer, Jeffrey Bush

Cellular organization and boundary formation in craniofacial development.

Genesis (New York, N.Y. : 2000)

Kindberg AA, Bush JO

Editorial Introduction.

Developmental biology

Bush JO, Andersson ER

Editorial Introduction.

Developmental biology

Bush JO, Andersson ER

Live Imaging of Mouse Secondary Palate Fusion.

Journal of visualized experiments : JoVE

Kim S, Prochazka J, Bush JO

Cellular dynamics of tissue fusion in craniofacial development and orofacial clefting.

The FASEB Journal

Jeffrey O. Bush, Seungil Kim, Bronwyn Hagan

EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.

Stem cell reports

Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO

Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.

The Journal of cell biology

O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO

Convergence and extrusion are required for normal fusion of the mammalian secondary palate.

PLoS biology

Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO

Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.

Developmental dynamics : an official publication of the American Association of Anatomists

Agrawal P, Wang M, Kim S, Lewis AE, Bush JO

The society of craniofacial genetics and developmental biology 35th annual meeting.

American Journal of Medical Genetics Part A

Ophir D. Klein, Jeffrey O. Bush, Sarah M. Knox, Andrew H. Jheon, Dwight R. Cordero, Joan T. Richtsmeier

The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling.

Developmental biology

Lewis AE, Vasudevan HN, O'Neill AK, Soriano P, Bush JO

Ephrin B1 maintains apical adhesion of neural progenitors.

Development (Cambridge, England)

Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A

Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches.

Seminars in cell & developmental biology

Bush JO, Soriano P

Ephrin-B signaling in craniofacial development and disease.

The FASEB Journal

Jeffrey Ohmann Bush, Philippe Soriano

Analysis of signaling downstream of ephrin-B1 during development.

Developmental biology

Jeffrey O. Bush,Philippe Soriano

The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival.

Genesis (New York, N.Y. : 2000)

Chen J, Bush JO, Ovitt CE, Lan Y, Jiang R

Development of the upper lip: Morphogenetic and molecular mechanisms.

Developmental Dynamics

Rulang Jiang, Jeffrey O. Bush, Andrew C. Lidral

Development of the upper lip: morphogenetic and molecular mechanisms.

Developmental dynamics : an official publication of the American Association of Anatomists

Jiang R, Bush JO, Lidral AC

Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.

Developmental dynamics : an official publication of the American Association of Anatomists

Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, Maltby KM, Lidral AC, Jiang R

The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.

Proceedings of the National Academy of Sciences of the United States of America

Bush JO, Lan Y, Jiang R

The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis.

Gene expression patterns : GEP

Bush JO, Maltby KM, Cho ES, Jiang R

Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene.

Developmental dynamics : an official publication of the American Association of Anatomists

Bush JO, Lan Y, Maltby KM, Jiang R