Julie Sneddon, PhD | Department of Cell & Tissue Biology

Associate Professor

Cell and Tissue Biology

+1 415 502-3380

The primary focus of Dr. Sneddon’s research is the niche in pancreatic development and Type I Diabetes. Her research group employs the tools of stem cell biology, developmental biology, genomics, and tissue engineering. Dr. Sneddon’s laboratory studies the underlying biology of the cellular microenvironment, including the cellular diversity and lineage relationships of the non-epithelial compartment of the pancreas in the context of organogenesis, adult organ function, and disease. The hope is that a deeper understanding of the identity and biology of non-epithelial “niche” cell types within the pancreas will enable a more directed and efficient attempt at replacing lost cell and organ function via regenerative medicine.

Publications

Replenishable prevascularized cell encapsulation devices increase graft survival and function in the subcutaneous space.

Bioengineering & translational medicine

Chendke GS, Kharbikar BN, Ashe S, Faleo G, Sneddon JB, Tang Q, Hebrok M, Desai TA

Single-cell chromatin accessibility of developing murine pancreas identifies cell state-specific gene regulatory programs.

Molecular metabolism

de la O S, Yao X, Chang S, Liu Z, Sneddon JB

Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass.

Developmental biology

Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O

Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.

iScience

Patzek S, Liu Z, de la O S, Chang S, Byrnes LE, Zhang X, Ornitz DM, Sneddon JB

Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation.

Hepatology (Baltimore, Md.)

Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts C, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN

Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective.

Cell metabolism

Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.

Nature communications

Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV

A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane.

Cell stem cell

Frumm SM, Yu SK, Chang J, Artichoker JA, Scaria SM, Lee KP, Byrnes LE, Sneddon JB, Tward AD

A single-cell atlas and lineage analysis of the adult Drosophila ovary.

Nature communications

Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG

Beta Living through Alpha Cells.

Cell stem cell

Patzek S, Sneddon JB

Pancreatic development: one cell at a (pseudo)time.

The EMBO journal

Liu Z, Sneddon JB

Lineage dynamics of murine pancreatic development at single-cell resolution.

Nature communications

Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype.

The Journal of clinical investigation

Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Cell stem cell

Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M

Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.

Development (Cambridge, England)

Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM

Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes.

Cell

Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD

Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.

Stem cells (Dayton, Ohio)

Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.

Nature

Sneddon JB, Borowiak M, Melton DA

The contribution of niche-derived factors to the regulation of cancer cells.

Methods in molecular biology (Clifton, N.J.)

Sneddon JB

Location, location, location: the cancer stem cell niche.

Cell stem cell

Sneddon JB, Werb Z

The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans.

Proceedings of the National Academy of Sciences of the United States of America

Welm AL, Sneddon JB, Taylor C, Nuyten DS, van de Vijver MJ, Hasegawa BH, Bishop JM

When should one subtract background fluorescence in 2-color microarrays?

Biostatistics (Oxford, England)

Scharpf RB, Iacobuzio-Donahue CA, Sneddon JB, Parmigiani G

Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.

Proceedings of the National Academy of Sciences of the United States of America

Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO

Predicting a local recurrence after breast-conserving therapy by gene expression profiling.

Breast cancer research : BCR

Nuyten DS, Kreike B, Hart AA, Chi JT, Sneddon JB, Wessels LF, Peterse HJ, Bartelink H, Brown PO, Chang HY, van de Vijver MJ

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival.

Proceedings of the National Academy of Sciences of the United States of America

Chang HY, Nuyten DS, Sneddon JB, Hastie T, Tibshirani R, Sørlie T, Dai H, He YD, van't Veer LJ, Bartelink H, van de Rijn M, Brown PO, van de Vijver MJ

Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.

PLoS biology

Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO