
Assistant Professor
Cell and Tissue Biology
The Choksi Lab studies how airway stem cells differentiate to build and maintain the respiratory epithelium. We focus on multiciliated cells - specialized epithelial cells that protect the lung by clearing inhaled pathogens. By combining mouse genetics, single-cell technologies, and imaging-based approaches, we aim to uncover novel principles underlying multiciliated cell differentiation. Our long-term goal is to identify new therapeutic strategies for restoring cellular function in respiratory disease.
Publications
Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions.
Cell reports
Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions.
bioRxiv : the preprint server for biology
An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.
Current biology : CB
Flow-Cytometric Analysis and Purification of Airway Epithelial-Cell Subsets.
American journal of respiratory cell and molecular biology
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Developmental cell
Hsd11ß2 Is Enriched in Medulloblastoma and Generates Ciliary Oxysterols to Stimulate Hedgehog Signaling.
International Journal of Radiation Oncology • Biology • Physics
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Developmental biology
Systematic discovery of novel ciliary genes through functional genomics in the zebrafish.
Development (Cambridge, England)
Switching on cilia: transcriptional networks regulating ciliogenesis.
Development (Cambridge, England)
Identifying gene regulatory networks that control adult regeneration in zebrafish.
Developmental biology
Corrigendum to “Specification of vertebrate slow-twitch muscle fiber fate by the transcriptional regulator Blimp1” [Dev. Biol. 324 (2008) 226–235].
Developmental biology
Specification of vertebrate slow-twitch muscle fiber fate by the transcriptional regulator Blimp1.
Developmental biology
Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells.
Developmental cell
Turning back the clock on neural progenitors.
BioEssays : news and reviews in molecular, cellular and developmental biology