Adjunct Professor
Cell and Tissue Biology
The Klefström Lab investigates how oncogene-driven cancers acquire targetable vulnerabilities for precision therapy. Our research focuses on MYC-driven metabolic dependencies, particularly on mitochondrial function, as therapeutic opportunities in aggressive breast cancers and other refractory tumors. We develop pharmacological and combinatorial strategies to target these liabilities, including approaches that enhance anti-tumor immunity. In parallel, we use patient-derived tumor explant platforms to preserve the tumor microenvironment and rapidly test therapies directly in human cancer tissue.
Publications
Drug-Free Approach to Regulate Undruggable Proto-Oncogene MYC Using Biomimetic Porous Nanoparticles for Cancer Immunotherapy.
ACS applied materials & interfaces
Nanofibrillar Cellulose Hydrogels with Anionic Surface Modifications for Modulating Macrophage Phenotype in 3D Culture.
ACS applied materials & interfaces
Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses.
Oncoimmunology
Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment.
Journal for immunotherapy of cancer
Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis.
Molecular oncology
Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.
Scientific reports
Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells.
Advanced healthcare materials
MYC-an emerging player in mitochondrial diseases.
Frontiers in cell and developmental biology
Laminin matrix adhesion regulates basal mammary epithelial cell identity.
Journal of cell science
Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Nature communications
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Nature communications
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer.
Nature communications
Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin.
Cancer research
UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis.
Cancer research
Strain-Stiffening of Agarose Gels.
ACS macro letters
Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.
Nature communications
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.
Nature communications
Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology.
Journal of medicinal chemistry
Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform.
Journal of medicinal chemistry
Phenotype-driven identification of epithelial signalling clusters.
Scientific reports
Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture.
Methods in molecular biology (Clifton, N.J.)
MYC and AMPK-Save Energy or Die!
Frontiers in cell and developmental biology
Myc requires RhoA/SRF to reprogram glutamine metabolism.
Small GTPases
MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures.
Cell cycle (Georgetown, Tex.)
Par6 family proteins in cancer.
Oncoscience
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.
The EMBO journal
Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.
Cancer discovery
Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.
Proceedings of the National Academy of Sciences of the United States of America
Faulty epithelial polarity genes and cancer.
Advances in cancer research
Regulation of cell death in human fetal and adult ovaries--role of Bok and Bcl-X(L).
Molecular and cellular endocrinology
GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis.
Endocrine-related cancer
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation.
International journal of cancer
3D view to tumor suppression: Lkb1, polarity and the arrest of oncogenic c-Myc.
Cell cycle (Georgetown, Tex.)
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization.
Proceedings of the National Academy of Sciences of the United States of America
c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc.
Cell cycle (Georgetown, Tex.)
c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis.
The EMBO journal
[Lentiviruses to use].
Duodecim; laaketieteellinen aikakauskirja
c-Myc augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway.
The Journal of biological chemistry
Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro.
Cancer letters
Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation.
The EMBO journal
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma.
Blood
Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin's lymphomas.
Leukemia research
Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterisation.
European journal of haematology
Myc protein: partners and antagonists.
Critical reviews in oncogenesis
A sub-set of immediate early mRNAs induced by tumor necrosis factor-alpha during cellular cytotoxic and non-cytotoxic responses.
International journal of cancer
[Complex mechanics of tumor-necrosis-factor-induced cell death].
Duodecim; laaketieteellinen aikakauskirja
[The use of polymerase chain reaction in the diagnosis of non-Hodgkin's lymphoma].
Duodecim; laaketieteellinen aikakauskirja